Publications

Sophia Millington-Ward, Naomi Chadderton, Mary O'Reilly, Arpad Palfi, Tobias Goldmann, Claire Kilty, Marian Humphries, Uwe Wolfrum, Jean Bennett, Peter Humphries, Paul F Kenna and G Jane Farrar (2011) Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa
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Farrar GJ, Palfi A, Kenna, PF, O'Reilly M. (2010) Gene-based Therapies for Dominant Retinopathies. Curr Gene Ther. 10: 381-388.

Palfi A, Millington-Ward S, Chadderton N, O'Reilly M, Goldmann T, Humphries MM, Li T, Wolfrum U, Humphries P, Kenna PF, Farrar GJ (2010). Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene. Hum Gene Ther. 21: 311-323.

Chadderton N, Millington-Ward S, Palfi A, O'Reilly M, Tuohy G, Humphries MM, Li T, Humphries P, Kenna PF, Farrar GJ (2009). Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy. Mol Ther. 17: 593-599.

O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin TC, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ. (2008). A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa. Vision Research 48: 386-391

O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ (2007). RNA interference-mediated suppression and replacement of human rhodopsin in vivo. Am J Hum Genet. 81: 127-135.

Palfi A, Ader M, Kiang AS, Millington-Ward S, Clark G, O'Reilly M, McMahon HP, Kenna PF, Humphries PF, Farrar GJ. (2006) RNAi-based suppression and replacement of RDS-peripherin in retinal organotypic culture. Hum Mutat 27: 260-268.

Kiang AS, Palfi A, Ader M, Kenna PF, Millington-Ward S, Clark G, Kennan A, O'reilly M, Tam LC, Aherne A, McNally N, Humphries P, Farrar GJ (2005). Toward a gene therapy for dominant disease: validation of an RNA interference-based mutation-independent approach. Mol Ther. 12: 555-561.

Millington-Ward S, O'Neill B, Tuohy G, Al-Jandal N, Kiang AS, Kenna PF, Palfi A, Hayden P, Mansergh F, Kennan A, Humphries P, Farrar GJ (1997). Strategems in vitro for gene therapies directed to dominant mutations. Hum Mol Genet. 6: 1415-1426.